To aid in the identification of narcolepsy without cataplexy, we review key indicators of narcolepsy and present a diagnostic algorithm. In this report, we review the clinical and physiological aspects of narcolepsy without cataplexy, the limitations of available diagnostic procedures, and the differential diagnoses, and we propose an approach for more accurate diagnosis of narcolepsy without cataplexy.Ī group of clinician-scientists experienced in narcolepsy reviewed the literature and convened to discuss current diagnostic tools, and to map out directions for research that should lead to a better understanding and more accurate diagnosis of narcolepsy without cataplexy.
11 Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ĭiagnosing narcolepsy without cataplexy is often a challenge as the symptoms are nonspecific, current diagnostic tests are limited, and there are no useful biomarkers.10 Department of Biomedical and Neuromotor Neurological Sciences, University of Bologna, and IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.9 Sleep Medicine Children's National Med Center, Washington, DC.8 Tokyo Metropolitan Institute of Sleep Science, Tokyo, Japan.7 National Reference Network for Orphan Diseases (Narcolepsy), Department of Neurology, Hôpital Gui de Chauliac, CHU Montpellier, INSERM U1061, France.6 Department of Neurology and Program in Sleep, Emory University School of Medicine, Atlanta.5 Hôpital Pitié-Salpêtrière, Pierre and Marie Curie University, Paris, France.4 Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.3 Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.2 Stanford Center for Sleep Sciences, Stanford University, Stanford, CA.1 Department of Neurology, University Hospital Zurich, Zurich, Switzerland Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
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